Peritubular Myoid Cells Are Not the Migrating Population Required for Testis Cord Formation in the XY Gonad
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چکیده
منابع مشابه
Sertoli Cells Maintain Leydig Cell Number and Peritubular Myoid Cell Activity in the Adult Mouse Testis
The Sertoli cells are critical regulators of testis differentiation and development. In the adult, however, their known function is restricted largely to maintenance of spermatogenesis. To determine whether the Sertoli cells regulate other aspects of adult testis biology we have used a novel transgenic mouse model in which Amh-Cre induces expression of the receptor for Diphtheria toxin (iDTR) s...
متن کاملPdgfr- mediates testis cord organization and fetal Leydig cell development in the XY gonad
During testis development, the rapid morphological changes initiated by Sry require the coordinate integration of many signaling pathways. Based on the established role of the platelet-derived growth factor (PDGF) family of ligands and receptors in migration, proliferation, and differentiation of cells in various organ systems, we have investigated the role of PDGF in testis organogenesis. Anal...
متن کاملErythropoietin expression in primary rat Sertoli and peritubular myoid cells.
Kidney and liver are the major organs of erythropoietin (Epo) synthesis. However, Epo messenger RNA (mRNA) has been detected in several organs, such as brain, lung, and testis. Furthermore, functional Epo receptors have been demonstrated on different cell types, including rat Leydig cells. The aim of the study was to identify testicular cells expressing Epo mRNA and to quantitate its levels by ...
متن کاملReply to Chen and Liu: Role of GDNF from peritubular myoid cells in the testis stem cell niche.
Chen and Liu (1) agree with our main conclusion that glial cell line-derived neurotrophic factor (GDNF) produced by peritubular myoid (PM) cells signals to undifferentiated spermatogonia and regulates their maintenance (2), but argue that a PM cell-specific gene knockout is impossible because the myosin heavy polypeptide 11 smooth muscle-Cre (Myh11-Cre) is not expressed specifically in PM cells...
متن کاملSertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis.
Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their role during the intervening period of testis development, in particular during adult Leydig cell (ALC) differentiation and function, remains largely unknown. To examine SC function during fetal and prepubertal development we generated two t...
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ژورنال
عنوان ژورنال: Sexual Development
سال: 2008
ISSN: 1661-5433,1661-5425
DOI: 10.1159/000143430